【摘要】 本文报告吡喹酮对犬斯氏狸殖吸虫作用的透射电镜观察。动物一次口服吡喹酮120mg/kg后24h,皮层细胞质突起肿大,基质中分泌体减少,线粒体固缩;合体细胞核仁及染色质溶解,内质网减少;实质细胞核肿大,胞质中糖原颗粒减少;肌纤维肿胀、溶解,肌微丝排列紊乱;肠上皮细胞核及核仁肿大,染色质凝集,胞质中分泌体消失,表面微绒毛粘连,断裂。更多还原

【Abstract】 Transmission. electron microscopical observations on the effects of pyquiton on po-gumogonimus skrjabini in dogs were carried out. 24 hours after oral administration of single dose of 120mg/kg pyquiton to dogs infected with Pagumogonimus skrjabini, the tegumental cytoplasmic projections swelled, the mitochondria in the ground substance; were concentrated, the secretory bodies decreased, the nucleolus and chromatin in the tegumental cells and the musculature were dissolved and the muscular microfilaments were disordered. Simultaneously, the nucleus and nucleolus of the gut epithelia were swollen, the chromatin concentrated, the secretory body disappeared and the microvilli on the surface of digestive tract adhered together and ruptured. Finally, the mechanism of pyquiton in killing Paragonimus was discussed on the basis of the findings in this study (Plates 1-8).更多还原