【摘要】 本实验通过建立一个轻度高T₄血症的大鼠模型,来研究血清T₄升高而T₃正常时对垂体和心脏所产生的生物学效应。结果表明,不仅垂体和心脏内的T₃明显升高,而且垂体TSH分泌的抑制和心肌中三种同功肌浆球蛋白—V₁、V₂和V₃的组成都产生了类似甲亢大鼠的变化。更多还原

【Abstract】 A mild hyperthyroxinemic rat model, characterised by elevated serum T4 and suppressed serum TSH, but normal serum T3 levels, was established by daily injection with T4 to thyroideotomised rats. The biological consequences of mild hyperthyroxinemia were investigated in the pituitary and heart of the model by measuring intracellualr thyroid hormone, serum TSH and ventricular isomyosins (V1, V2 and V3). The results not only revealed raised intracellu-lar T3 levels in the presence of normal serum T3 level, but also demonstrated the suppressed serum TSH and the shift in distribution of 3 isomyosine were similar to what happened in hyperthyroid rats.更多还原