【摘要】 本文报道经导管肝动脉内注入碘油丝裂霉素乳剂(LME)治疗肝癌的实验研究和临床应用。LME使丝裂霉素包围在油相之中,随碘油停留在肿瘤局部缓慢释放。注入后周围血药浓度测定和r闪烁扫描证明,药物在肿瘤局部有相当高的浓度而在周围血中浓度最低。可利用X线平片和CT观察随访肿瘤的变化。20例患者术后半年生存率达85%,3例已生存一年。更多还原

【Abstract】 Twenty patients with hepatoma were treated by transcatheter hepatic intraarterial infusion of lipiodel-mitomycin C emulsion(LME). The mitomycin C (MMC) was envcloped in lipiodol, remained in tumcr tissue to release slowly. After the injection of LME, by determining the peripleral bleed and ruclide scanring, it showed that the MMC-concentration was fairly high in tumor and quite low in peripheral blocd. The change of the tumor cculd be followed up by plain radiograph and CT. Eighty-five per cent of the patients survived more than six months.Three cases of them survived even more than one year.更多还原