【摘要】 <正> 头孢菌素合成常采用混合酸酐法、DCC法、活化酯法等肽类合成方法。羰基二咪唑（简称CDI,I）法也属肽类合成方法。最近有文献报道,将此法用于头孢菌素C₃·位乙酰氧基的改造以及氨苄青霉素α-氨基的修饰。但用于头孢菌素C₇位缩合未见报道。本文采用更多还原

【Abstract】 CDI(N,N’-Carbonyldiimidazole) acylating agent was used in direct condensation for the synthesis of cephalosporins. The application of CDI in the preparation of 7β-(6-Substituded-2-quinolone-3-acetamido)-cephalosporins was studied. The reaction conditions under which the synthesis is accomplished were discussed and the preliminary comparison with other methods was made. The method could be satisfactorily applied to the synthesis of cephalosporins, since the procedure was simple and efficient and proved useful particularly for the carboxylic acids with active hydrogen containing-bulky substituted group. The method could also be widely used for the research of semisynthetic cephalosporins.更多还原