【摘要】 <正> 飞蓬甙(erigeroside)是从灯盏花(Erigeron breviscapus)中提取的一种水溶性成分。药理试验证明灯盏花的水煎剂具有活血化瘀作用。业已鉴定3-羟基-4-吡喃酮及其甙类(飞蓬甙,飞蓬双糖甙)为主要水溶性成分。但这些成分分离困难,收率也低。本文报道飞蓬甙的全合成以及它的药理活性研究。更多还原

【Abstract】 Erigeroside and 3-hydroxy-4-pyranone, water-soluble constituents of Erigeron breviscapus, were synthesized and their activities investigated.The primary pharmacological studies showed that erigeroside and 3-hydroxy-4-pyranone (dose 0.86 mg/ml PRP) inhibited significantly platelet aggregation induced by ADP in vitro. The inhibiting aggregatory rates(%) of erigeroside and 3-hydroxy-4-pyranone were 32.6% and 37.6% respectively. 3-Hydroxy-4-pyranone could accelerate the blood flow of arteriolae and venulae, relieving mesenteric microcirculatory disturbances induced by noradrenaline.更多还原