【摘要】 从贝母新种——宁国贝母(Fritillaria ningguoensis S. C. Chen et S. F. Yin)鳞茎中分离出五个生物碱,其中碱V是一种新的生物碱,命名为宁贝新(ningpeisine),根据理化常数和光谱解析以及衍生物制备,测定其结构为N-methyl-3β-hydroxy-5α-veratranine-6-one。其余四种生物碱鉴定为浙贝甲素(peimine,verticine,Ⅰ),浙贝乙素(peiminine,verticinone,Ⅱ),异浙贝甲素(isoverticine,Ⅲ)和贝母辛(peimisine,Ⅳ)。更多还原

【Abstract】 Ning-Guo Bei Mu, a new substitute for the traditional Chinese medicine Bei Mu （Fritillaria verticillata Willd）, has been used for antibechie and expectorant. From Ning-Guo Bei Mu （the bulbs of Fritillaria ningguoensis S. C. Chen et S. F. Yin）five alkaloids including a new veratranine alkaloid were isolated. By spectral analysis (IR, MS, ¹HNMR ¹³CNMR) and preparation of derivative the structure of this new alkaloid （Ⅴ） was elucidated as N-methyl-3β-hydroxy-5α-veratranine-6-one, named Ningpeisine. The known alkaloids were identified as verticine, verticinone, isoverticine and peimisine.更多还原