【摘要】 Oxy明显地抑制凝血酶诱导洗涤的兔血小板聚集,IC₅₀为254μmol/L,对MDA的生成也有抑制作用。ASA不能对抗凝血酶引起的血小板聚集,但能显著抑制MDA的生成。提示,Oxy抑制血小板聚集的作用可能与影响PAF生成有关,对MDA生成的抑制可能影响了AA的游离。更多还原

【Abstract】 Oxyfedrine (Oxy ) exhibited inhibitory effect on washed rabbit platelet aggregation and MDA production induced by thrombin (4 U /ml) . The concentration of Oxy causing 50% inhibition of platelet aggregation induced by thrombin was 254 μmol/L . Up to 2 nig/ml, acetysalicylic acid (ASA) could not antagonize platelet aggregation induced by thrombin 。 However, ASA 50 μg/ml reduced the generation of MDA markedly. These results suggest that anti-aggregation of Oxy may be related to inhibition of PAF formation and the effect of Oxy on MDA generation may be due to the inhibition of arachi-donic acid release.更多还原