【摘要】 峨嵋唐松草碱10mg/kg,可以显著提高乌头碱诱发大鼠及哇巴因诱发豚鼠致心律失常用量;能明显地预防氯仿所致小鼠心室纤颤的发生;能显著对抗大鼠心肌缺血复灌引起的心律失常。峨嵋唐松草碱对大鼠心电图的影响,表现为显著的减慢大鼠心率,延长P—R及Q—Tc间期。更多还原

【Abstract】 Methoxyadiantifoline 10 mg/kg i.v. significantly increased the arrhythmia- inducing dose of aconitine in anaesthetized rats, and that of ouabain in anaesthetized guinea pigs. It markedly prevented ventr icular fibrillation induced by chloroform. Methoxyadiantifoline is also effective in preventing reperfusion-induced arrhythmias in anaesthetized rats. It was demonstrated that methoxyadiantifoline slowed heart rate significantly, and prolonged P-R and Q-Tc interval of ECG in rats.更多还原