【摘要】 作者观察了胰管内注射胰蛋白酶和胆汁所致犬急性胰腺炎(AP)时血流动力学变化及多巴胺对 AP 的治疗作用。治疗组在制 AP 模型后10min 开始静脉持续3h 滴注多巴胺,持续3h,每小时0.6mg/kg。AP 组的胰腺血流量(PBF)在制 AP 后迅速下降,全身血流动力学也发生了明显改变。多巴胺治疗可增加 PBF,改善全身血流动力学,降低 AP 犬的死亡率和减轻胰腺炎程度。提示多巴胺可通过改善 AP 早期的胰血供,有效地阻止水肿性胰腺炎向出血坏死性胰腺炎发展。更多还原

【Abstract】 A dog model was used to measure the hemodynamic changes during acute pancre- atitis(AP)by intraductal injection of fresh trypsin-bile mixture and to investigate the efficacy of dopamine in AP.Dopamine was administered intravenously at a dose of 0.6mg/kg/h 10 min after induction of AP for three hours.Hemorrhagic pancrea- titis was characterized by a fall in CO,SAP,an increase in PVR,SVR and the development of early reduction of pancreatic blood flow(PBF).Administration of dopamine produced a significant increase in PBF and led to a normalization in CO, SAP,PVR and SVR.In addition,dopamine significantly reduced the severity of the AP,as assessed using both histological staging and mortality rate.These reaults sug- gest that dopamine appears to limit the progression of the pancreatitis from edematous to hemorrhagic and irreversible pancreatic damage through preserving PBF at the early phase of AP.更多还原