【摘要】 本文用放射免疫方法测定了妊娠高血压综合征妇女血浆中前列环素与血栓素稳定代谢产物的含量,结果发现,妊高征妇女血浆中6-Keto-PGF_1α的含量明显低于正常妊娠组;而TxB₂的含量高于正常妊娠组。提示前列环素与血栓素的变化与妊高征的病理生理变化有关。更多还原

【Abstract】 In order to investigate the kinetic changes of prostacyclin and thromboxane A₂ concentrations and study the relationship between them and the effects on the normal pregnancy and EPH-syndrome, 6-Keto-PGF₁α and TxB₂ levels in the plasma, the stable metabolites of PGIz and TxA₂ were measured by radioimmunoassay on the non-pregnant women （30 cases）, the normal pregnant women（77 cases）and the patients with EPH-sydrome （35 cases）. The results showed that 6-Keto-PGF₁α levels in the plasma was significantly lower （P<0.05） and TxB₂ was significantly higher（P<0.05）than that of normal pregnant women. It is suggested that the changes may be involved in the pathology mechanism of the EPH-syndrome development.更多还原