【摘要】 <正> 淋巴细胞浸润肿瘤组织的现象已被广泛注意,但对TIL的抗肿瘤作用进行研究只是近二三年才开始。这主要是由于基因工程技术的进步,使人们可以获得大量纯一的重组白细胞介素2(rIL-2),从而可进行TIL的活化,增殖,扩增的研究。我们用人rIL-2对更多还原

【Abstract】 We Investigated antitumor activity of tumor infiltrating lymphocytes(TIL) obtained from human carcinomous tissue. The results showed: 1) a large number of TIL could be obtained from tumor tissue by methods of enzymic isolation and Ficoll gradient centrifugation. The ratio of TIL and tumor cells varied in the samples; 2) after incubation of TIL with rIL-2 lymphoblasts appeared in the culture. Aggregates consisting of fast-growing cells were observed; 3) TIL from 5 lung tumor samples demonstrated significant cytotoxic activity against NK-resistant Anip targets after co-culture with rIL-2. Further investigations on other antitumor properties of TIL are being continued.更多还原