【摘要】 本实验利用标准玻璃微电极技术和微机系统的实时应用,在离体豚鼠右心室乳头肌上观察维生素D₃对其细胞电活动的影响。结果表明维生素D₃可使心肌细胞动作电位和零相最大去极化速率发生明显改变,其变化主要是由于通过细胞膜慢通道有大量的Ca²⁺内流,使细胞内Ca²⁺超负荷来实现的。更多还原

【Abstract】 The effects of the vitamin D₃ on electrical activities in papillary muscle cells of guinea pigs were observed and recorded by means of the standard glass microelectrode technique and microcomputer system. The results showed that the APA, OS and RP were all decreased, maximum upstroke velocity of phase O depolarization was also decreased, the APD was shortened, especially APD₅₀ was shortened most obviously. It is suggested that Ca²⁺ inward current was increased, so intracellular Ca²⁺ overload happened when vitamin D₃ was used, thus cardiac muscle damage being induced.更多还原