【摘要】 本文报告了16例石棉肺并发肺内恶性肿瘤的尸检资料,并从病理角度出发予以分析和讨论。其中10例的接尘浓度为20-149.1mg/m~8,平均接尘工令为17.3年。肺内硅酸盐尘量经化学测定在0.19-0.95mg/100mg(干肺)。16例中腺癌5例,肺泡细胞癌3例,未分化癌6例,鳞癌和胸膜间皮瘤各1例。作者认为,石棉纤维不仅是致纤维化的直接病因,亦是使上皮或间皮增生并恶变的始动因素。其组织起源是在石棉肺病变基础上支气管或肺泡上皮以及问皮增生并恶变,或是上皮先有化生再间变和癌变.更多还原

【Abstract】 Sixteen autopsies of asbestosiscomplicated with intrapulmonarymalignant tumor were reported,As-bestos concentration at workplacewere recorded as 20-149.1 mg/m~3.The average year of exposure was17 years. Chemical analysis showed thatthe content of silicate were 0.19-0.95 mg in 100 mg dried lung tissue. The histologic types of 16 mali-gnancies were:5 adenocarcinoma, 3alveolarcarcinoma,6 undifferentia-ted carcinoma, I squamous carcino-ma and 1 mesothelioma of pleura. Authors mentioned the asbestosfibres were not only the etiologicfactor of fibrosis but also initia-ting the epithelium proliferationand malignant transformation. As to the histologic origin, au-thors suggested that on the base offibrotic lesions of asbestosis, thereare proliferative changes of bron-cheolar,alveolar epithelium and me-sothelium in pleura and then cance-rous transformation, or the epithe-lium of bronchial mucosa has meta-plasia first then followed by anap-lasia and tumor formation.更多还原