【摘要】 本文在地方甲状腺肿和克汀病病区检查了516人的甲状腺功能。人群甲低检出率为69.4%,儿童的检出率高于成人。以血清 TSH 检查甲低的检出率最高。在儿童,以血清 T₄或TSH 检出甲低的检出率比 T₃为高。在成人,T₃或 TSH 检出甲低的检出率比 T₄为高。若仅以常用的血清 T₄和 TSH 二项指标检查甲低,其漏检率分别为3.6%、28.6和14.8%,表明血清 T₃是不可缺少的检查项目。T₄、T₃和 TSH 三参数相关分析结果是:在儿童和成人,T₄与 TSH 呈负相关;T₃与 T₄呈正相关;在儿童血清 T₃与 TSH 呈负相关。更多还原

【Abstract】 The main objective of thispaper is to review and analyzethese results in order to reachthe conclusions concerning themethodology for detection of hypo-thyroidism of inhabitants in theareas of endemic goiter and creti-nism.With serum T4,T3 and TSHmeasurement,385 (69.4%) of 516residents belonged to hypothyroid-ism.The incidence of hypothyroid- ism in children was higher thanthat in adults.The data withTSH alone was the most sensitiveone in detecting hypothyroidismamong 516 inhabitants.In children,the detection rateof hypothyroidism obtained byusing T4 or TSH was higher thanthat by T3,while in adults T3 orTSH was more efficient than T4.With T4 and TSH combined,3.6%of 197 hypothyroid children,28.6%of 161 hypothyroid adults and 14.8%of 305 hypothyroid inhabitants willbe missed.It is very clear that theT3 examination in detecting hypo-throidism should not be negligible.The correlation coefficients ofdifferent hormonal parameters ofpituitary thyroid axis were as fo-llows:In children and adults therewas a definite reversed correlationbetween T4 and TSH and definitereversed correlation between T4 andT3.In children,there was definitereversed correlation between T3and TSH.更多还原