【摘要】 为了进一步探讨磷脂代谢障碍和膜损伤在克山病发病中的意义,对低硒低磷脂半合成饲料喂养的动物,作了较系统的实验研究结果表明,动物血硒及组织 GSH-Px 活性降低,组织的荧光色脂质增加,心电及心肌的超微结构出现异常,补硒可以改善上述改变、但对心肌的脂质组成,细胞色素氧化酶活性均不能恢复正常,只有同时补充硒和磷脂(尤其内源性磷脂)时,才能充分达到正常对照的水平。更多还原

【Abstract】 The pathogenetic significance ofmetabolic disorder of phospholipidand membrane damage in Keshandisease were studied by feedingyoung guinea pigs with a semipur-ified basal diet low in selenium andphospholipid.The blood seleniumand tissue glutathione peroxidaseactivity were lowered,fluorescentchromolipid in tissues was elevated.The molar ratio of myocardialcholesterol /phospholipid wasncreased,cardiolipin (diphosph-atidylglycerol) content and activityiof cytochrome oxidase in myocar-dium and cAMP level in plasmawere decreased.Electrocardiogramof animals fed with basal diet wasabnormal,ultrastructure of myoc-ardial membrane system revealedlesion and DNA content in myoc-ardium decreased.These changes was slightlyimproved by selenium supplement-ation,but only when both phosp-holipid and selenium were givensimultaneously bib restored tonormal evlel.更多还原