【摘要】 98例心律失常患者静脉应用常咯啉注射液500mg/d,滴注4h或8h/d×2d,显效率为78％,总有效率88％,大多数在30min内起效。22例在滴注后1、2、3和4h的血浆浓度分别为2.7±0.5,2.7±0.6,2.6±0.6及2.8±0.6μg/ml。本药对频繁房性早搏、室性早搏,短阵室速,室性平行心律均有明显效果,在静脉滴注过程中无不良反应。对阻抗心动图除Q-Z间期和Heather指数外,其他各项指标均无明显影响。小剂量静脉推注或连续静脉滴注常咯啉治疗心律失常患者的结果表明,常咯啉是一种安全有效的抗心律失常药物。更多还原

【Abstract】 98 patients with acute arr hythmia, received changrolin intravenously 500 mg/d gave a significant effectiveness 78% and a total effectiveness 88 %. The plasma concentrations of changrolin in 22 patients were 2.7 ± 0.5, 2.7 ±0.6,2.6±0.6and 0.8?0.6μg/ml at the ends of 1st, 2nd, 3rd and 4th hour respectively during iv drip. changrolin was found to be quite effective in multiple atrial extrasystole, ventricular extrasys-tole, paroxysmal attack of ventricular tachycardia and ventricular parasystole. With the exception of Q-Z interval and Heather Index, here were no significant cardiac functional changes or adverse reactions ever noted.It is deeply impressed that changrolin, given in small dose by intravenous dripping, is safe and reliable to control arrhythmia.更多还原