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冠心病人血清中抗单纯疱疹病毒Ⅰ型IgG抗体检测
Detection of IgG Antibodies to HSV-1 in Sera of Coronary Heart Disease Patients
【摘要】 用 ELISA 和 RIA 技术检测冠心病人、老年非冠心病病人及正常献血员各30例的血清中抗 HSV-Ⅰ型 IgG 抗体水平。结果表明:正常献血员血清中抗HSV-Ⅰ型 IgG 抗体的水平高于老年病人组(P<0.01),但与冠心病人组无差异(P>0.05)。作者认为这一结果并不能完全否定病毒感染在动脉粥样硬化发病中起一定的作用,并进行了讨论。ELISA 和 RIA 均具有简便、灵敏、稳定可靠、微量等优点,其结果呈直线正相关(r=0.76)。
【Abstract】 The IgG antibody to HSV-I in 30 patients with coronary heart disease, in 30 with other diseases and in 30 normal donors were detected by the methods of ELISA and RIA.The results showed that the level of IgG to HSV-I,in the donor group was higher than that of other disease group (P< 0.01),but there was no difference from the coronary heart disease group (P>0.05).We think that this result cannot rule out the role of HSV-I in the pathogenicity of atherosclerosis.Our test also showed that ELISA and RIA were simple,sensitive and reliable,and both methods had higher straight line correlation(r=0.67).
【Key words】 atherosclerosis; IgG; herpesvirus hominis; enzyme-linked immunosorbent assay; radioimmunoassay;
- 【文献出处】 湖北医学院学报 , 编辑部邮箱 ,1987年01期
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