【摘要】 本文报告经淋巴管内灌注多联抗癌药物治疗晚期或复发转移恶性肿瘤31例,其中恶性淋巴瘤8例,胃癌8例,卵巢癌8例,直肠肛管癌4例,其他癌3例,除1例纵膈恶性淋巴瘤外,全部经病理证实。男性19例,女性12例,年龄从30～67岁,平均年龄48.8岁,每次灌注剂量,胃癌、直肠癌、卵巢癌用甲氨喋啶150mg+5-Fu2000mg+环磷酰胺1200mg;恶性淋巴瘤用环磷酰胺1600mg+甲氨喋啶150mg。治疗结果12例取得完全或部份缓解,总的有效率为38.7％,对恶性淋巴瘤和卵巢癌疗效较好,认为淋巴管内灌注抗癌药物能提高一些肿瘤的切除率和治愈率,化疗反应轻,值得推广应用。更多还原

【Abstract】 Intralymphatic polychemotherapy was performed in 31 patients with advanced or recurrent malignant neoplasms, including 8 malignant lym-phomas, 8 gastric cancers, 8 ovarian cancers, 4 colo -rectal cancers and 3 other malignancies. Pathological diagnosis were available in all cases except one cases of mediastinal malignant lymphoma. Of the 31 cases there were 19 males and (?)The ages (?)years caverage 48.8 years(?). Thedrugs used in the intraiyphat ic polyehemotherapy were as follows; (1) Me thotrexat e 150mg (?) Fluorouracil 2000mg + Cyclophosphamide 1200mg or thio-tepa 100 - 150mg for adenocarcinoma. (2) Cyclophosphamide 1600mg+Methotrexate 150mg for lym-phoma. The objective response rate (CR+PR) in this series was 38.7%.Good response were obtained in the malignant lymphomas and ovarian cancers.The authors believed that the resectable rate and cure rate in some malignant tumors were increased after intralymphatic polychemotherapy.更多还原