【摘要】 本文研究了姜黄对兔和大鼠实验性心肌缺血和对离体兔心灌流量的影响,姜黄的主要有效成份姜黄素对营养性心肌血流量的影响和毒性试验。结果表明,姜黄对兔和大鼠实验性心肌缺血有保护作用,对离体兔心有直接扩张冠脉、显著增加冠脉流量的作用,姜黄素有显著增加营养性心肌血流量的作用更多还原

【Abstract】 The protective effect of Curcuma Longa Rhizome (CLR) on ischemic myocardium was studied in rats and rabbits. The electrocardiographic pattern of ischemic myocardium induced by pituitrin 0.4 iv, was effectively protected by CLR fluidextract (p<0.01). In isolated rabbit heart, the coronary arterial spasm induced by pituitrin 0.4, could be effectively antagonized by CLR fluidextract, and the coronary outflow was dramatically increased. It was found by means of 86Rb method, that there was a significant increase in nutritional blood flow in myocardium of mice in respo nse to curcumin (active principle of CLR).The acute toxicity of CLR is rather low. In the subacute toxicity study,There was no significant histopathological change to be found in the heart, liver, kidney, aorta, brain, and adrenal glands.Our data suggest that the CLR and its active principle may be useful for preventing and treatment of angina pectoris更多还原