【摘要】 在9只失血性休克狗(平均血压维持在40mmHg)观察其球结膜微循环,并定期从股动脉采血检查血液和血浆比粘度、红细胞比容、血小板聚集和红细胞变形能力。结果:一、微循环反应非常敏感,放血后数分钟球结膜微动收缩,血流速度变慢,红细胞出现聚集;休克期镜下可见毛细血管数目减少,血流停滞,红细胞重度聚集。二、血液流变学检查:放血停止后,血液和血浆比粘度,红细胞比容均明显下降;血小板聚集加强;红细胞变形能力的变化发生较晚,休克后一小时开始降低。三、回输失去的血液和生理盐水后,微循环和血液流变学诸指标都趋向恢复。作者分析了失血性休克狗微循环和血液流变学的关系。更多还原

【Abstract】 The experiments were carried out by means of continuous observation of bulbar conjunctival microcirculation and periodical determination of blood and plasma visbosities, hematocrit, platelet aggregation and erythrocyte de-formabilityat different stages of hemorrhagic shock in 9 dogs (BP 40mmHg). The results showed that the responses of microcirculation occurred soon after the beginning of bleeding: the microvessels constricted, the blood flow velocity decreased and the erythrocytes aggregated. The microcirculatory condition became worse during the shock stage: the number of capillaries decreased, erythrocytes sluge appeared and blood flow slowed down and even stopped.The Theological examinations of the arterial blood were as as follows: when bleeding arrested the blood viscosity and hematocrit wre decreased and the platelet aggregation became exacerbated. But the deerease in erythrocyte deformability appeared rather late, it started 1 hour after bleeding. All of the changes (including microcirculation and hemorheological data) recovered gradually in response to retransfusion of the shed blood and normal saline. Lastly. the authors analysed the relations between the disturbances of microcirculation and the changes of rheological factors.更多还原