【摘要】 本文研究结果发现,蕨和毛叶蕨除引起肝、肾和心等实质细胞肿胀外,并具有明显的致瘤能力,其肿瘤发生例数分别为11/20和15/22。蕨在W大鼠引起的肿瘤为:肠道肿瘤(3/10);膀胱肿瘤(6/10)。在S—D大鼠只引起膀胱肿瘤(4/10)而无其它肿瘤。毛叶蕨在W大鼠引起的肿瘤;肠道肿瘤(5/12);膀胱肿瘤(5/12);甲状腺肿瘤(2/12);卵巢肿瘤(1/12);皮下肿瘤(1/12)。在S—D大鼠引起的肿瘤为:肠道肿瘤(3/10);膀胱肿瘤(3/10),肿瘤发生率在蕨和毛叶蕨组间以及大鼠品系之间均无明显统计学差异(P>0.1)。肠道肿瘤主要发生于回肠,往往会导致肠套叠或类套叠变化,但未见有肿瘤转移现象,在20只对照大鼠未见任何肿瘤发生。更多还原

【Abstract】 This is a part of the experiments on animal models to study the feasibility of the combined efforts to prevent and cure the toxic and tumorigenic the effects of two ferns (Pteridium aquilinum and P. revolutum)on chronic enzootic hematuria of cattle. Histopathogical examination indicated that the two ferns could cause swelling of the liver cells, cardiac muscles and the epithelial cells of the convoluted tubules of the kidneys. Besides, it possessed vigorous tumorigenic effects. The tumor incidence in the two strains of rats caused by P.aquilinum and P.revolutum were 11/20 and 15/22 respectively. Intestinal tumors (3/10) and bladder tumors (6/10) were detected in Wistar rats fed with P.aquilinum, while only bladder tumors (4/10) were fouud in S—D rats fed with the same fern. Intestinal tumors (5/12), urinary bladder tumors(5/12), thyroid gland tumors(2/12), ovarian tumor (1/12), and subcutis tumor (1/12)were obtained from Wistar rats fed with P. revolutum, while only intestinal tumors (3/10) and urinary bladder tumors (3/10) were discovered in S—D rats fed with the same fern. No signficant differences were found on tumor incidance either between the two ferns or between the two strains of rats(P>0.1). The intestinal tumors occurred mostly in ileum and could lead to intussusception or intussusception-like changes. No metastasis was found in all tumor-bearing rats. And on neoplastic growth was identified from the 20 control rats.更多还原