【摘要】 本文在国内首次报导用自己合成的特丁基异腈制备成功^99mTc-TBI标记物.采用药盒标记法,沸水浴中反应1min（或80℃,反应5min）即可完成.鉴定表明,^99mTc-TBI的标记率及放化纯度均在98％以上,产物无需分离,即可直接用于静脉注射.通过对小白鼠、家兔的研究表明,该标记物在正常心肌中有较高的浓集和较长的保留时问,同时具有相当快的血清除率,是良好的心肌灌注显像剂.该标记物用于国内临床研究亦获成功.更多还原

【Abstract】 The t-butylisonitrile compound is synthesized. The cationic complex Tc- 99m hexakis （t-butylisonitrile） technetium （TBI） is labelled by kit method. The reaction is accomplished in boilling water for 1 min（or at 80℃ for 5 min）. The labelling efficiency and radiochemical purity of ^99mT-TBI are both more than 98%. The animal studies indicate that ^99mTc-TBI is an excellent myocar- dial perfusion imaging agent. It has had succese in human bodies as well.更多还原