【摘要】 酮基布洛芬是一种新的非激素类抗炎镇痛药。作者对66例典型的类风湿性关节炎病人用此药(150mg/日)治疗,疗效满意者36例(54.5%),总有效率为87.9%。其中24例还采用酮基布洛芬和消炎痛作了对照互换试验,两者疗效无显著差异,但酮基布洛芬的副作用明显少而轻。酮基布洛芬是一种较满意的治疗类风湿性关节炎新药。更多还原

【Abstract】 Ketoprofen 2-(3-benzoylphenyl)-propionic acid, a new non-steroidal anti-inflammatory analgesic drug, has been reportedly effective in the management of rheumatoid conditions. In open clinical trials 66 patients with typical rheumatoid arthritis at various stages have been treated. The age of the patients ranged from 15-76 years. The capsule of ketoprofen (130mg/day) which synthesized by Chongqing Southwest Synthetic Pharmaceutical Factory has been given for 2 weeks to each patient and the result was evaluated at the end of each trial. Overall excellent and good results were obtained in 87.9%. Besides this study, a cross-over contrast trial was carried out in 24 patients of 66 cases. Each patient was given in dosages of 150mg daily of ketoprofen and indomethacin 75mg daily for a period of 2 weeks. Although subjective assessment of the effect favoured indomethacin, there was no significant difference between the two drugs. Fewer mild side-effects were observed with ketoprofen as compared with indomethacin. Authors pointed out in conclusion that local made ketoprofen is a safe, reliabe and effective drug for rheumatoid arthritis with the same potency as the imported material.更多还原