【摘要】 本文对各种肝脏疾病210例,包括原发性肝癌100例,转移性肝癌10例,肝硬化47例,慢性肝炎29例,急性肝炎10例和阻塞性黄疸14例,分别进行r-谷氨酰转肽酶(γ-GT)、5’-核苷磷酸二酯酶(5’-NPDase)同功酶测定。 γ-GT同功酶Ⅰ’、Ⅱ、Ⅱ’带主要是见于原发性肝癌组,100例中67例有Ⅰ’、Ⅱ、Ⅱ’带,占67%;有Ⅰ’带者7例,占7%;有Ⅱ’带者5例,占5%;在肝硬化组中有Ⅱ带者2例,占4%(2/47);一例郁胆性肝炎出现Ⅰ’带,占3%(1/29)。 38例原发性肝癌中28例出现5’-NPDase同功酶Ⅴ带。占73.6%;转移性肝癌6例中4例有Ⅴ带,占66%;肝硬化中有2例出现Ⅴ带,占10%(2/20)。 原发性肝癌AFP阴性和低滴度阳性者11例。其中出现γ-GT-Ⅱ带者7例,占63%,出现5’-NPDase-Ⅴ带者9例,占81％。若将r-GTⅡ带和5’-NPDase-Ⅴ带互相补充,可提高阳性率100%。更多还原

【Abstract】 Y-Glutamyl transpeptidase (Y-GTP) and 5’-Nucleotide phosphodiesterase (5’-NPDase) isoenzymes were studied in 210 cases of various liver diseases, including 100 cases of hepatocellu-lar carcinoma, 10 metastatic liver carcinoma, 47 liver cirrhosis, 29 chronic hepatitis, 10 acute hepatitis and 14 obstructive jaundice.Y-GTP isoenzyme I’, II, II’ were found in.7%, 67% and 5% of hepatocellular carcinoma respectively, Y-GTP I could also be found in 2/47 (4%) cases of cirrhosis, and Y-GTP I ’ in a case of chronic hepatitis.5’NPDase V was found, in 28/38 (73.6%) cases of hepaiocellular carcinoma, in 4 out of 6 cases in metastatic liver carcinoma and in 2 out of 10 cases in cirrhosis,Combination of Y-GTP and 5’NPDase isoenzyme positive in 38 cases of hepatocellular carcinoma could raise the positive rate to 97%, and similarly from 63% and 81% to 100% in H cases of hepatocellular carcinoma with normal or low titer of serum AFP.更多还原