【摘要】 将感染日本血吸虫家兔分为每日、间日注射醋酸可的松(ACT)25mg和对照组3组进行观察。结果表明注射ACT者,特异性抗体的产生受到显著抑制;其中每日注射者肝组织内血吸虫虫卵肉芽肿病变的减弱程度和血吸虫虫卵的活性与得量的增高,均较间日注射者为显著。因此,可应用免疫抑制方法提高感染兔肝组织内的虫卵得量,以供免疫学研究应用。更多还原

【Abstract】 Two experimental groups of rabbits, 4 weeks following percutaneous exposure to Schistosoma japonicum cercariae, were injected intramuscularly with 25mg of cortisone acetate (ACT) daily and every other day respectively. All rabbits were autopsied to isolate the eggs from the livers, and pathological sections are prepared 2 weeks after ACT injection, i.e., 6 weeks after exposure. The production of specific schistosomal antibody in rabbits injected with ACT appeared to be markedly suppressed. The formation of schistosome egg granulomas was remarkably diminished while the proportion of reactive schistosome eggs in the livers increased, and the average number of ova in animals injected with ACT daily is 1.64 times that in control rabbits, but the two parametres are less pronounced in rabbits injected with ACT at one day intervals. It is suggested that the immunosuppressive method reported here may be utilized to increase the recovery of schistosome eggs from the livers of infected animals.更多还原