【摘要】 <正> 内眦赘皮是双眼内眦部的一种半月形皮肤皱襞。有不少作者把它列为某种疾病的诊断体征之一。现就此问题,作者将1981年对成都市6岁以下汉族儿童11,462人调查中所发现的388例内眦赘皮资料进行分析,探讨国人汉族儿童内眦赘皮的遗传问题,以及它与遗传性疾病、特别是与遗传性综合征的关系。同时还对它的基因频率进行计算和探讨。更多还原

【Abstract】 388 cases of epicanthus were found from an investigation of 11,462 Chinese children aged 0-6 at Chengdu in 1981. The incidence was 3.12% in males and 3.67% in females; the incidence in the family members of the 388 children was 26.27%. The difference between the population and familial incidence rates was highly significant.Although it was apparent that epicanthus had definite relationship with heredity according to the result of pedigree analysis in this series, there was no definite and significant associated defect except mongolian palpebral fissure. Also the data of IQ examinations and investigation of dermatoglyphics revealed nothing abnormal.It was concluded that(a) epicanthus was a kind of hereditary characters, but not necessarily a sign of different hereditary diseases, and (b) two types of genetic modes of epicanthus of Chinese children were found in the investigation(autosomal dominant and recessive); and the gene frequency for epicanthus in the children was 0.14063.更多还原