【摘要】 <正> 生育异常的问题与遗传和优生密切有关。目前,国内外对女性生育异常(包括原发闭经、不孕、不明原因习惯性流产及不良生育等)细胞遗传学的研究较多,但对男性生育异常,尤其是男性不育缺乏较系统的研究。本文对100例不育男性从染色体异常的类型及其发生率,可能影响男性生育能力和质量的有关因素更多还原

【Abstract】 100 cases of male infertility were cytogenetically studied. 70 of these infertile men had azoospermia and 30 had oligozoospermia(consistant sperm count below 10 million/ml). Chromosomal preparations made from peripheral blood lymphocytes were analysed by conventional, GTG and CBG banding techniques in all cases and additionally by high resolution chromosome (HRC) G-banding and silver-staining(NOR-Ag) in some cases. The types and incidences of chromosomal abnormalities were as follows:1. 47, XXY(11%); 46, XY/47, XXY(2%); 47, XYY(1%). 2. 46, XY, del(13)(p11)(1%); 46, XY, del(Y)(q12)(1%). 3. 45, XY, rob(14; 21)(p11.1; q11.2)(2%); 45, XY, rob(13; 14)(p11; q11.2)(1%); 46, XY, t(13; 18)(p11; q11.2)(1%); 46, XY, t(1; 13)(q22; q32)(1%). The overall incidence of chromosomal abnormalities was 21%; the incidence for the azoospermia group was 28.6% and that for the oligozoospermia group 10%(exclusive of variant chromosomes and minor abnormalities). It seems that the incidence of the abnormalities of infertile males in Chinese was higher than those reported in foreign literature. The authors emphasized that cytogenetic screening for cases of male infertility and subfertility may be of value and importance from the viewpoint of family planning and eugenics. The possible factors that might have effects off male fertility and fertile quality were discussed, with the question whether Robertsonian and reciprocal translocation and the whole or deletion of 13p were responsible for male infertility in particular.更多还原