【摘要】 <正> 鼠疫活菌苗用于人群自动免疫已为众所熟知,其流行病学效果已被确认。免疫学效果测定现多采用间接血凝试验。但在工作实践中发现当动物抗体逐渐下降或消失后仍能抵抗毒菌的再感染。此现象引起了学者们对细胞免疫的重视。我们曾用体外淋巴细胞转化试验(以下简称淋转试验)观察鼠疫活菌苗接种豚鼠后的细胞免疫动态,并证明豚鼠血凝抗体消失后细胞免疫指标之一的淋转率更多还原

【Abstract】 The immunologic responses of forty young workers inoculated with liveplague vaccine (EV) were studied. The serum specimens were taken atvarious periods for detection of FI antibody of Y.pestis with IHA;the Ea rosette test was made with micro--whole blood technique and the lymphocytetransformation in vitro by adding stimulating agent lectine(PHA) or F1antigen of Y.pestis respectively,for comparing with ehe control ofwithout stimulating agent.Results showed that the geometric mean of IHA antibody titers as thoseinoculated after the first month was 1:6.209,at the end of the third month,all of the antibody titers were 1:10;whereas after three months of immun-ization the Ea rosette test and lymphocyte transformation rates all showed asignificant difference (P<0.001) than those of before inoculation.Theindexes of cellular immunity were higher than those of humoral immunity andthey maintained a high level. Results also showed that there was no signif-icant difference (P>0.05) between the lymphocyte transformations withstimulating agent (PHA or F1) or on stimulating agent after inoculation.更多还原