【摘要】 1-四氢巴马汀(1-THP)和四氢小檗碱(THB)与dl-THP一样都能降低脑内单胺和升高酸性代谢产物DOPAC,HVA和5-HIAA。它们作用的强弱次序为dl-THP<1-THP<THB。四氢黄连碱和四氢药根碱仅观察到对边缘区多巴胺有较弱的降低作用,但对纹状体和边缘区的酸性代谢产物升高明显。小檗胺、盐酸巴马汀、盐酸小檗碱和甲基小檗碱则未显示出对脑内单胺有明显影响。更多还原

【Abstract】 Investigation of some isoquinoline alkaloids on monoamine metabolism in rat brain was conducted using HPLC-electrochemical detection. It was found that 1-tetrahydropalmatine (1-THP) and dl-tetrahydroberberine (dl-THB), 60 mg/kg ip, like dl-THP, a known short-term monoamine depletor, lowered monoamines and raised acidic metabolites (DOPAC, HVA and 5-HIAA) in the striatum and limbic area. But, the effect of dl-THP was much stronger than that of 1-THP. This may mean that d-THP is more active than 1-THP. The potency of dl-THB was found to be the weakest of the three alkaloids, dl-Tetrahydrocoptisine and dl-tetrahydrojatrorrhizine induced a slight reduction of dopamine only in the limbic area. However, both alkaloids markedly increased acidic motabolites in the striatum and limbic area. No significant changes on monoamines in rat brain was produced by berbamine, palmatine chloride, berberine chloride and 13-methylberberine iodide at doses of 60 mg/kg 30 min after intraperitoneal injection.更多还原