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中药柞木抑制小鼠前胃鳞状上皮增生与癌变的研究

Quercas variabihis blume inhibits squamous epithelial hyperplasm of mouse forestomach.A study on carcinomatous lesions

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【作者】 千高峰; 和瑞芝; 袁松杨; 杜花贞; 张中庆; 付怀平; 任金平; 苏志梅; 郭子秀; 常东明;

【Author】 Department of Pathology XinxiangMedical College Qian Gao—feng

【机构】 新乡医学院病理教研室; 新乡医学院病理教研室; 新乡中药厂; 新乡医学院药理教研室;

【摘要】 食管上皮的癌前病变,是食管癌变过程中的必经阶段,具有两向转化的特性,阻断其癌变,已成为试图降低癌的发病半、死亡率的关键所在。柞木对食管癌前及癌变上皮的生长有明显阻断或逆转作用,经三次重复实验柞木抑制癌变率达50%左右。在治疗剂量下(40g/Kg),未出现毒性作用;加大到200g/Kg,仍未有特殊改变。

【Abstract】 It is the necessary stage of carcinoma of the esophagus that the precancerous lesions of esophageal epithelium transfer to cancer, which posseses the characteristics of two aspects both favourable and unfavourable in its course of pathogenesis.To arrest the preca- ncerous lesions of the esophagus is the key of decreasing the incidence and mortality of the disease.This article reports Quercas Veriabihis Blume has the obvious effect on arresting and reversing the growth before and after the epithelial lesions of cancer.The effect of Quercas Valiabihis Blume upon cancer lesions was repeated experimentally for three times to prove that the ratio of controlling cancer development is 50% and there is no toxic effects with the dose below 40g/Kg,even up to 200g/Kg.

【关键词】 柞木; 小鼠; 胃肿瘤; 治疗学;
【Key words】 Za—mu; Neoplasm of mouse Stomach; treament;
  • 【文献出处】 新乡医学院学报 ,Journal of Xinxiang Medical College , 编辑部邮箱 ,1985年01期
  • 【被引频次】5
  • 【下载频次】30
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