【摘要】 对21名男性原发性高血压患者进行了红细胞⁸⁶R_b摄取率测定。与22名男性正常血压者相比,患者的哇巴因敏感⁸⁶摄取率降低R_b提示男性原发性高血压患者的红细胞钠泵活性降低。患者组的哇巴因敏感⁸⁶R_b摄取率与血压负相关;而正常血压组这一组分的摄取率与血压不相关,但与年龄负相关。二组间其它摄取组分均无差别。本文还对原发性高血压患者红细胞钠泵活性低下的意义和原因作了讨论。更多还原

【Abstract】 Erythrocytes ⁸⁶Rb uptake was studied in 21 male patients with essential hypertension and in 22 sex and age matched normotensive controls. In patients with essential hypertension, the rate of total ⁸⁸Rb （K⁺） uptake was significantly lower than that in the normotensives （23.20±3.39 mol K+/mg dry weight RBC/h vs27.16+5.10 mol K+/mg dry weight RBC/h,P<0.01）,which was due to a reduced Ouabain-sensitive ⁸⁶Rb（K⁺） uptake （16.24+3.27 mol K+/mg dry weight RBC/h vs 20.76±4.31 mol K⁺/mg dry weight RBC/h, P<0.001）. In the hypertensives, the Ouabain-sensitive ⁸⁶Rb（K⁺） uptake rate was negatively correlated with their systolic blood pressure and mean blood pressure, while in the normotensives, the uptake rate was negatively correlated with their years of age. The Ouabain-insensitive Furosemide-sensitive and Ouabain-insensitive Furosemide-insensitive ⁸⁶Rb uptakerates were similar in the hypertensives and in the normotensives. A circulating Na⁺-K⁺-ATPase inhibitor may he responsible for the decreased sodium pump activity in hypertension.更多还原