【摘要】 收集两年来人鼻咽癌活检材料190 例,进行了三种酶的组化研究。结果表明:癌组织的乳酸脱氨酶活性增高,兰色颗粒在胞浆内,特别是未分化癌细胞显示清晰不规则的细胞核,有助于临床诊断;大部分癌组织酸性酯酶活性消失或减弱,仍有部分病例保持相当的酶活性;而β-葡萄糖醛酸酶活性则呈阴性反应。更多还原

【Abstract】 Since 1982, histochemical and cylochemical-enzymic studies have been carried out in the dinitrosopiperazine induced rat nasopharyngcal cancer tissue. In this investigation human nasopharyngeal cancer biopsied tissues were used for enzyme observation. The results were as follows. The lactic dehydrogenase activity was higher in the cancer than in normal epithelial cells, just as that seen in the experimental materials. In the lower or undifferentiated cancer tissues the blue stained graunles scattered in the cancer cell cytoplasm around the nuclear membrane. This proved a very clear picture of the irregular shape and size of the tumor cell nuclei and thus favored the pathological diagnosis. As to the acid esterase the result was somewhat different from the experiment tissues. The enzyme dissimilarity or disequilibrium was discussed briefly. The β-glucuronidase in the NPC tissue revealed negative result. This was different from some other reports.Through this study we obtained information concerning the enzymes of human NPC. It is hoped that further study using biochemical method will be made in order to facilitate olinical diagnosis.更多还原