【摘要】 对6头猪（29.92±4.01公斤）单剂量静注15毫克/公斤的氯霉素,药后分别在0.08、0.25、0.5、1、2、3、4小时收集血样,用分光光度计测定血清中氯霉素浓度。血药浓度一时间曲线符合开放二室模型。由模型算出的药物代谢动力学参数如下:瞬时血药浓度（C°p）34.75±15.24（微克/毫升）;分布半衰期(t_1/2α)0.07±0.02（小时）;消除半衰期(t_1/2β)1.59±0.70（小时）;药时曲线下面积（AUC）31.23±5.79（微克×小时/毫升）,表观分布容积（Vd）1.08±0.33（100毫升/公斤）,清除率（Cl_B）0.50±0.09（小时×100毫升/公斤）,有效浓度维持时间（Tcp（ther））2.05±0.27（小时）。更多还原

【Abstract】 Chloramphenicol was administered to six pigs (29.92±4.01kg) by single intravenous injection at dosage of 15mg/kg . body weight. Samples of blood were collected at 5,15 and 30 minutes and 1, 2, 3, and 4 hours after the drug was injected. Serum levels of chlorampenicol were determined by spectrophotometer . The concentration-time curve of drug was fitted for a two-compartment open model . Pharmacokinetic parameters of chloramphenicol were as follows. C°p 34.75±15.24 (mcg./ml. ) ; t1/2α 0.07±0.02(hr. ) ; t1,2β1.59±0.70 (hr.) , AUC 31.23±5.79 (hr. mcg./ml. ) ; Vd 1.08± 0.33 (100ml/kg. ) ; ClБR0.50±0.09 (hr. 100ml./kg. ) ; Tcp(ther)2.05±0.27 (hr. ) .更多还原