【摘要】 本研究给家兔注射胰岛素或喂甲状腺素,以观察体内LPL、H-TGL活性的改变。结果表明这两种激素对血浆PHLA(LPL+H-TGL)影响相同;而对不同组织的LPL有不同的作用。同时观察了血浆脂蛋白水平的改变,结果分析表明:注射胰岛素后HDL水平的升高作同PHLA升高正相关(r=0.852,P<0.05);喂甲状腺素后LDL水平升高同PHLA升高正相关(r=0.920,P<0.05)。结果提示。不同组织LPL活性的改变对脂蛋白代谢有不同的影响,脂肪组织LPL活性的升高可能有助于HDL水平的升高。更多还原

【Abstract】 This article shows our experimental results: (1) Both insulin and thyroxin raised the level of plasma PHLA in rabbits significantly (P<0.01). (2) Insulin enhanced both the LPLA in adipose tissue (P<0.05) and the H-TGLA in liver (P<0.01), but there was no significant effect on heart and skeleton muscle. Thyroxin significantly increased the LPLA in heart, skeleton muscle and the H-TGLA in liver (all P<0.01), while it decreased the LPLA in adipose tissue (P<0.01). (3) After injecting insulin, the increase of plasma HDL was positively correlated with PHLA (r=0.852 P <0.05). on the other hand, after administratinlg thyroxin, the increase of plasma LPL was positively correlated with PHLA (r=0.920 P<0.05). (4) The above observations suggested that to maintain the appropriated ratio of LPLA between adipose tissue and skeleton muscle is an important factor in maintaining the most proper ratio between the plasma level of HDL and LDL, and in turn is important in the prevention and treatment of atherosclerosis.更多还原