【摘要】 <正> 为寻找高效低毒抗肿瘤新药,60年代初期中国医学科学院药物研究所在环磷酰胺临床有效的基础上,自行设计研制了以氨基酸为载体的氮芥磷酰胺衍生物。取名甘磷酰芥(Glyciphospboramide,曾用名M—25,6202)。此药为白色粉末,结构为:更多还原

【Abstract】 From 1978 to 1984,16 cancer patients were treated here with M—25,a new anti-neoplastic drug which was first synthesized by the Institute of Materia Medica, Chinese Academy of Medical Sciences. 10 patients with advanced breast cancer, 2 squamous cell carcinoma of theskin and a reticalum cell sarcoma respond well to the drug, others with advanced gastri cancer and one Hodgkin’s disease did not respond to the drug at all. The results of this trial group is: complete regression 2 cases, partial regression 7 cases and no response in another 7 cases.Both M25 0.5g given by mouth twice a day either continuously or intermittently and local application of 10％ M25 in DMSO solution twice daily for 4 or more weeks were well tolerated by most patients.The main side effects were problems in thedigestive tract (12/16), and bone marrow depression (8/16).No toxicity in the liver or kidney, alopecia or irritation to the urinary bladder were observed.更多还原