【摘要】 以前研究表明除草剂胺草灵在一定剂量时能引起小鼠精母细胞染色体畸变,小鼠显性致死试验阳性,尚能诱发小鼠精子畸形。作者以雄性Caston-S野生型与雌性Muller-5果蝇进行胺草灵伴性隐性致死试验。胺草灵剂量为0、100、300、500mM和阳性对照物MMS50μM.试验结果:致死率分别为0.28、0.25、0.58、1.11和3.54％。高剂量组及MMS与空白对照组比较,有非常显著意义(P<0.01),且有剂量效应关系。这表明胺草灵对生殖细胞能引起可遗传的基因突变。更多还原

【Abstract】 Previous studies reported that amiprophos gave rise to chromosomal aberration of spermatocyte, positive result in the dominant lethal test and increase of sperm with abnormal morphological changes. We carried out a recessive lethal test on amiprophos with wild type Caston-S male drosophila and Muller-5 female drosophila. The dosages were 0.100, 300, 500mM of amiprophos and 50 μM of MMS for positive control. Experimental results revealed lethality rates were 0.28, 0.25, 0.58, 1.11 and 3.54% respectively. Comparison of tie results of the high dosage groups of amiprophos and of MMS with that of the negative control (P<0.01) showed marked significance as well a dose response. The study indicates that amiprophos might cause transmissible gene mutation in germ cells.更多还原