【摘要】 本文报道³H-氧甲基山豆根碱的药物代谢动力学。大白鼠一次灌胃给药后,血浆药物浓度对时问的曲线符合开放式二室模型。其主要参数是:t1/2_Ka=0.203hr t1/2_a=0.481hr,t1/2_β=9.429hr, K₁₂=0.582hr^-1, K₂₁=0.799hr^-1, K₁₀=0.132hr^-1, T_max=0.61hr, C_max=0.461μg/m1。收集48小时内大白鼠的粪、尿测得排出的放射性分别为21.59%和1.97%更多还原

【Abstract】 The pharmacokinetics of tritium-O-methyldauricine was studied in rats. The logarithm of drug concentration in plasma versus time curve after oral administration was fitted to a two-compartment open model with first order elimination. The pharmacokinetic parameters are as follows: Distribution half-life 0.48hr, Elimination half-life 9.43hr, Absorption half-life 0.2hr, Elimination rate constant 0.132/hr, Posi-tive transfer rate constant 0.582/hr, Converse transfer rate constant 0.799/hr, Peak concentration 0.461ng/ml, Time of peak concentration 0.6lhr. After oral administration, the radioactivities excreted in urine and faeces within 48 hours were determined directly ia rats. The radioactivities excreted in faeces and urine were 21.59% and 1.97% respectively.更多还原