【摘要】 本文比较了正常大鼠与奶油黄诱发肝癌大鼠的肝细胞中β-半乳糖苷凝集素的活性。用¹²⁵Ⅰ标记去唾液酸α₁-酸性蛋白(¹²⁵Ⅰ-ASOR)及辣根过氧化物酶标记去唾液酸α₁-酸性蛋白（HRP-ASOR）为示踪剂,证明肝癌细胞表面的β-半乳糖苷凝集素显著低于正常,在肝癌结节中近于消失。此消失与癌细胞转移是否有关,值得探索。更多还原

【Abstract】 The role of the mammalian lectins is not well known. Some of them may act as specific receptor for plasma glycoproteins, which are internalized through endo-oytosis and are finally degraded in cytosol. And some may take part in cell-cell recognition, adhesion and cell differentiation.The activity of β-galaotoside specific lectin of normal and cancer-beating rat liver cells was reported in this paper. The activity was measured both in vivo and in vitro. The life span of intravenously injected 125I-labelled orosomucoid (125I-ASOR) in blood and the accumulation of 125I-ASOR in liver were used as the indicator of the activity of the lectin in vivo. And indirect enzyme-conjugated immunohistoohemical method was used to detect the activity of lectin in tissue slices. The results of the study revealed a marked decrease of β-galactoside specific lectin in butter yellow induced liver cancer cells. The significance of this finding was discussed.更多还原