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饮食对MNNG在大白鼠诱发胃癌的影响

The Influence of Diet on Induced Gastric Tumor of Rats by MNNG

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【作者】 吴树朴; 梁法超; 夏惠芬; 姜鸷滋; 丁贞英; 辜小南;

【Author】 Wu Shupu Liang Fachao Xia Huifen (Department of Hygiene, Jiangxi Medical College) Jiang Zhizi (Department of Pathology, Jiangxi Medical College) Ding Zhenying Gu Xiaonan (Jiangxi Institute of Parasitic Diseases)

【机构】 江西医学院卫生学教研室; 江西医学院卫生学教研室; 江西医学院病理解剖学教研室; 江西省寄研所实验研究室;

【摘要】 为探讨降低胃癌发病率的措施,用出生8天的大白鼠,以灌胃途径每鼠每天给予MNNG 150μg,连给3天。至断奶时将每窝幼鼠都按性别及体重随机分为3组,各喂1种用常用食品搭配的饲料,至给MNNG后的第300天,断颈处死,做病理学检验。结果发现胃的癌前组织改变的程度与体重的增长无关,而与免疫力的高低呈反比;饮食成分可影响胃癌的发展,通过合理组织饮食对胃癌的发展有抑制作用。

【Abstract】 This study was undertaken to investigate the effects of diet on induced gastric tumor of rats geven the same amount of MNNG into stomach by Cat- heter during the newborn period.150ug MNNG in o.lml of distilled water at one dose was introduced into stomach for three times consecutively on the 8th,gth and 10th day after birth.After intubation the newborn rats were fed by their mother divided at random until weaning stage.Then, these rats were into three groups by their weight and size and fed by three different kinds of diet.The rats were killed 300 days after the first intubation. The stomach were examined grossly and histologically for tumor. The results of this experiment showed that the development of gastrie tumor can be influenced by diet.

  • 【文献出处】 江西医学院学报 ,Acta Academiae Medicinae Jiangxi , 编辑部邮箱 ,1984年04期
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