【摘要】 <正> 病毒性肝炎是一类在世界范围内广泛流行的消化系统传染病,近年来发现该病发病率有成倍增高的趋势,目前已成为一个严重的国际性卫生问题。其病原学的研究进展很快,但其发病机制尚不清楚。对免疫病理过程还有不同的看法。鉴于干扰素系统是公认的体内抗病毒感染的重要防御机制,具有保护细胞免受病毒侵害、抗肿瘤及调节体内免疫功能等更多还原

【Abstract】 Interferon (IFN) is an antiviral substance in the immune defence mechanism and it is accepted that IFN has many effects on the growth and functions of cells. In an attempt to observe the interf eron response to certain chronic viral infections a preliminary study was undertaken for the IFN inducing activity of human leukocytes in 141 cases of acute hepatits, 115 cases of chronic hepatitis,91 cases of cirrhosis and 25 cases of liver cancer. Heparinized blood samples from patients were incubated with NDV and the crude interf eron obtained was acidified, neutralized, titrated on human fetal lung diploid cells(by the cytopathic effect assay in microtiter plates) , and corrected for international reference interferon preparation. Results obtained were as follows(expressed as log4CPFI 50/ml) :4.85± 0.54 in the control group,4.23 ± 0.62 in acute hepatitis patients,3.76 ± 0.67 in chronic hepatitis,3.73 ± 0.70 in cirrhosis and 3.61 ± 0.57 in liver cancer.As a whole,the average level of inter-rferon produced by leukocytes in all of the experimental groups was significantly lower than that in the control group (P<0.01), and it was lower in chronic hepatitis, cirrhosis and liver cancer than in acute hepatitis (P<0.01) . The titer of induced interferon showed no significant difference in HBsAg negative and positive in the subgroups of each experimental group.Our results show that the pathogenesis and progress of these diseases seem to be related with a defective IFN response of the host, and suggest that the use of IFN or IFN inducer might be of therapeutic value.更多还原