【摘要】 应用Ag-Ⅱ技术,对13名长期口服“复方炔诺酮片”妇女和13名未服药妇女的核仁形成区及近端着丝粒染色体联合进行了研究。服药组和对照组的银染核仁形成区(Ag-NOR_s)、参与联合的银染近端着丝粒染色体(Ag-AAC)和银染近端着丝粒染色体联合(Ag-AA)在丹佛体制分组水平上呈随机分布,两组的Ag-NOR 众数和频率相近,表明“复方炔诺酮片”对服药妇女有活性的rRNA 基因的数量没有影响。服药组的每细胞Ag-AAC 数及每细胞的Ag-AA 数低于对照组,差异显著;表明“复方炔诺酮片”或许能降低服药妇女rRNA 基因的活性,但提示服药妇女不会增加产生染色体三体或易位患儿的风险。更多还原

【Abstract】 By the method of Ag-Ⅱ staining,the nucleolar organizer regions(NORs)and acro-centrics association were studied in 13 women taking oral contraceptive “Tablet Norethin-droni Compositae”over a long period and in 13 controls.The distribution of the Ag-stained NORs(Ag-NORs),the Ag-stained associated acro-centric chromosomes(Ag-AAC)and the Ag-stained acrocentrics association(Ag-AA)in thetablet users and controls was a random one in Denver Group Level.The similarity in mode and frequency of Ag-NORs in the two groups suggested thatthe“Tablet Norethindroni Compositae” had no effect on the number of active rRNAgene.The mean number of Ag-AAC per cell and that of Ag-AA per cell were less in the tabletusers than in control There wass.a significant difference.This suggested that“TabletNorethindroni Compositae” might decrease the activity of rRNA gene in women takingthe drugs,and that women taking the drugs did not increase the chance of bearing a childwith trisomy or translocation.更多还原