【摘要】 本工作通过脑内埋藏套管,向兔双侧侧脑室内注射微量八肽胆囊收缩素(CCK-8),观察对空腹血浆自由脂肪酸(FFA)和血糖浓度的影响,结果如下:(1)侧脑室内注射引起血浆FFA 浓度明显下降,但血糖浓度无明显改变,静脉注射,血浆 FFA 不仅未下降,反而明显升高,血糖浓度也无明显改变。(2)注射苄胺唑啉和心得安不能消除侧脑室注射 CCK-8所引起的血浆 FFA 下降。(3)注射阿托品和切断膈下迷走神经以阻断胆碱能神经的作用后,侧脑室注射 CCK-8不再引起血浆 FFA 浓度下降。从上述结果看来,侧脑室注射 CCK-8降低血浆 FFA 浓度的作用,不是由于 CCK-8吸收入血所致,而是脑内 CCK-8浓度升高所产生的特异作用。这个作用可能是通过迷走神经引起的,与交感神经活动的关系不大。更多还原

【Abstract】 Chronic experiments were performed on male rabbits provided with implantedcerebral cannula,through which synthetic CCK-8 was injected into the lateralventricles.The concentrations of plasma FFA and blood glucose were determined.The results were as follows:The concentration of plasma FFA markedly decreased after the intraven-tricular injection of CCK-8 in doses of 50 and 100 ng,while that of blood glucosedid not.When CCK-8 was administered intravenously,however,the plasmaFFA concentration showed an increase instead of a decrease.The mentionedeffects of intraventricular administration of CCK-8 were not abolished byinjection of regitine or Propranolol,but could be abolished by injection ofatropine or by vagotomy.更多还原