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抗癫痫新药“抗痫灵”治疗癫痫270例临床分析

A NEW ANTIEPILEPTIC DRUG "ANTIEPILEPSIRINUM" IN THE TREATMENT OF EPILEPSY——AN ANALYSIS OF 270 CASES

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【作者】 周正新

【Author】 Zhou Zheng-sxin Epilepsy Clinic, Dpartment of Internal Medicine, People’s Hospital Beijing Medical College

【机构】 北京医学院附属人民医院内科癫痫门诊

【摘要】 <正> 自1975年2月以来,我们用胡椒碱的衍生物之一“抗痫灵”,即3~4次甲二氧桂皮酰哌啶(3~4methylene-dioxycinnamoyl piperidine),治疗癫痫。经长期观察,疗效仍属肯定。现将系统服用抗痫灵1~5年的270例癫痫的疗效,总结如下:

【Abstract】 Antiepilepsirinum is a new antiepileptic drug. Its chemical structure is 3-4 methylene dioxycinnamoyl piperidide, being a derivative of piperine. In our clinic, we had not encountered any untoward side reactions in a series of 270 cases treated with Antiepilepsirinum in the past 5 years.The therapeutic effects of antiepilepsirinum in the treatment of 270 cases of epilepsy were as follows: marked improvement was observed in 35.5%, the total rate of response was 83.3%. In the treatment of 243 old patients with intractable epilepsy, marked improvement was obtained in 30.9±2.96%, while treating 25 untreated patients newly referred with grand mal, marked improvement was observed in 76±8.54%. These results showed that antiepilepsirinum can be used for the first choice drug in grand mal threapy. It may be used as sole therapy or can be added to existing therapy when the patient is inadequately controlled and it is well tolerated by all ages when given in the recommended dosage and suitable for long-term treatment.

  • 【文献出处】 北京医学院学报 , 编辑部邮箱 ,1981年01期
  • 【被引频次】5
  • 【下载频次】61
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