【摘要】 本文研究了在给服甲状腺素小鼠腹腔注射³⁵S-蛋氨酸后,肝脏中³⁵S-蛋氨酸及其中间产物³⁵S-半胱氨酸和最终产物³⁵S-牛磺酸的动力学变化。结果表明,³⁵S-半胱氨酸的生成相对减少;牛磺酸放射性峰出现提前;³⁵S-蛋氨酸及其中间产物³⁵S-半胱氨酸参入肝蛋白质,以及³⁵S-半胱氨酸和¹⁴C-甘氨酸参入肝谷胱甘肽减少。说明甲状腺素对蛋氨酸代谢途中之某些酶有抑制.更多还原

【Abstract】 Dynamic changes of 35S-methionine, 35S-cysteine ( intermediate product) and 35S-taurine ( end product ) in the liver of L-thyroxine treated mice after intraperitoneal injections of 35S-methionine have been studied. The changes were as follows. ( 1 ) the amount of radioactive cysteine formed from 35S-methionine was relatively decreased, ( 2 ) the peak of taurine radioactivity appeared earlier ( due to the accelerated excretion of taurine via kidneys and bile ducts ) and ( 3 ) incorporations of 35S-methionine and 36S-cysteine into proteins, and of 35S-cysteine and 14C-glycine into glutathione, were decreased (indicating inhibition of syntheses of both liver proteins and glutathione) . These results suggest that certain related enzyme in the metabolic pathway of methionine be inhibited by thyroxine.更多还原