【摘要】 本文用抗补体免疫酶法检查鼻咽部脱落细胞的EBNA,结果①79例鼻咽癌病人全部阳性,其阳性检出率比细胞学(87.3％)和组织学(91.1％)方法高;②4例初次检查EBNA阳性,但细胞学和组织学阴性者,3个月内复查也找到癌细胞;③18例头颈部其他肿瘤病人和21例胎儿全部阴性,并为细胞学和组织学方法所证实。这表明抗补体免疫酶法检查EBNA是特异和敏感的,有助于鼻咽癌的早期诊断。除了在鼻咽癌细胞发现EBNA外,在鼻咽部柱状上皮细胞和增生细胞也发现EBNA,这可能与EB病毒引起的癌变过程有关。更多还原

【Abstract】 Exfoliated cells from nasoparynx of patients with definite or suspected nasopharyngeal carcinoma were examined for EBNA by anticomplement immunoenzymatic method. All 79 NPC patients were found to have EBNA-positive carcinoma cells, while the positive rates of cytological and histolog-ical examinations were 87.3 and 91.1% respectively. Tumor cells from other benign or malignant tumors of head and neck or nasopharyngeal epithelium from dead fetus were negative for EBNA. 6 cases with EBNA-positive cells and negative cytological or histological findings were reexamined 1 week to 5 months later and finally proved to have carcinoma.Thus,the anticomplement immunoenzymatic method is specific, sensitive and useful for the early detection of NPC. EBNA was found also in normal columnar epithelium or hyperplastic cell of nasopharynx. This suggest that NPC be caused by EB virus.更多还原