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气相色谱-质谱法分析麻醉乙醚中杂质

DETERMINATION OF IMPURITIES IN ANAESTHETIC ETHER BY GC/MS METHOD

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【作者】 王维; 张雪梅; 孙曾培;

【Author】 Wang Wei, Zhang Xuemei and Sun Zengpei (National Institute for the Control of Pharmaceutical and Biological Products, Beijing)

【机构】 卫生部药品生物制品检定所; 卫生部药品生物制品检定所 北京; 北京; 北京;

【摘要】 用气相色谱-质谱联机,以国产高分子微球GDX-502为色谱柱填充剂,分析了以乙醇-硫酸法合成的麻醉乙醚中的杂质,共分出十三个杂质,确证了十个。它们是乙烯,丙烯,异丁烷,环丁烷,丁烯类化合物三个,甲基乙基醚,乙基异丙基醚,乙酸乙酯。

【Abstract】 The impurities in anaethetic ether were investigated by gas chromatographic-mass spectrometric method. GDX-502, a cross linked polystyrene beads was used as the column packing material. Thirteen impurities were discovered in anaesthetic ether, synthesized by ethanol-sulfuric acid method. Ten of them were identified. They are ethylene, propylene, isobutane, cyclobutane, three isomeric butenes, methyl ethyl ether, ethyl isopropyl ether, and ethyl acetate.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,1980年10期
  • 【被引频次】3
  • 【下载频次】62
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