【摘要】 本实驗利用蝕斑技术由对小白鼠皮下致死力較高的流行性乙型脑炎病毒京卫研₁株分离出10株皮下致死力高低不等的毒株。經小白鼠脑內連續盲传10代,証明其皮下感染力是比較稳定的,所选出的毒株的其他生物学性貭,如血凝性貭,在不同温度下培养时的蝕斑形成能力等,也有所不同,但其抗原性則仍相似。作者根据本实驗的結果,认为京卫研₁株病毒实际上不是由单一性貭的病毒顆粒所組成,而是由一些抗原性相似,但在某些生物性貭上不同的病毒顆粒所組成的羣落。此外,本文对自然界存在有不同毒力的脑炎毒株的可能原因进行了討論。更多还原

【Abstract】 In this experiment 10 virus strains of different subcutaneous pathogenicity on micehad been isolated from J.B.E.virus by means of plaque-selection method. The pathogenicity of these selected strains was proved to be stable by subsequenttransferring through mouse brain up to 10 passage.Certain differences in bio-logical properties,such as hemagglutination activity and plaque-forming ability on cultiva-tion at different temperature had also been observed between some of the selectedstrains.However,all of these had similar neutrallizing antigenicity. Basing on the above results,the authors suggest that the original virus strain (Pekingstrain) was not composed by homogeneous virus particles but really a mixed populationmade up of particles of different biological properties. Propable reason about the formation of different virulent strains found in naturewas discussed in the paper.更多还原