【摘要】 本实驗采用2只正常狗,2只腎型和2只神經源型高血压狗研究了利血平、中国蘿芙木总硷和双氫氯噻嗪对血压反应的影响。在給药前、給药第5—10天及停药后血压恢复到正常时,各測去甲腎上腺素升压反应及乙酰甲胆硷降压反应两次,同时观察脉搏变化。結果表明,利血平使去甲腎上腺素升压反应稍加强,蘿芙木总硷降低此升压反应,双氫氯噻嗪无影响。利血平及蘿芙木总硷使乙酰甲胆硷降压反应减少,前者还使乙酰甲胆硷引起的脉搏加速减少,后者无此作用。双氫氯噻嗪的作用不同,它使乙酰甲胆硷的降压反应显著加强,維持时間也延长,这一作用在高血压动物更为明显。神經源型高血压狗在服用双氫氯噻嗪时,注射乙酰甲胆硷引起的脉搏加速反应消失,在腎型高血压狗明显减弱,而在正常狗无改变或稍加强。双氫氯噻嗪对MeCh反应的影响在同时补充氯化鈉或氯化鉀时即不出現,但靜脉注入右旋醣酐以补充血浆容量时不能改变这項影响。本实驗的結果反映了三种降压药的作用机制不同。更多还原

【Abstract】 In the present experiment the influence of reserpine, total alkaloids of Rauwolfia verticillata(RVA) and hydrochlorothiazide(HCT)upon the blood pressure responses has been studied with two normotensive, two renal and two neurogenic hypertensive dogs. The presser response to noradrenaline(NA)and depressor response to metacholine(MeCh)were measured before, during and after the administration of each drug. The results showed that the presser response to NA was moderately enhanced by reserpine, but was reduced by RVA. No change, however, occurred during the administration of HCT. The depressor response to MeCh decreased with reserpine and RVA treatment. The changes in MeCh response in the case of HCT were dissimilar, e. g. the response was significantly increased and its duration prolonged. The increase of pulse rate which occurred normally after MeCh injection disappeared in neurogenic hypertensive dogs receiving HCT. It was also diminished in renal hypertensive dogs, whereas no change or a slight increase was observed in normotensive dogs. When NaCl (10—20 g/day) or KCl(2—5 g/day) was given per os to dogs receiving HOT the change in MeCh response as mentioned above did not appear. Intravenous infusion with 200—300ml 6% dextran dissolved in 5% glucose, however, did not affect such changes caused by HOT treatment. The difference in mechanism of the hypotonsive drugs studied has been discussed.更多还原