【摘要】 <正> 肿瘤免疫是治疗肿瘤的途径之一。我们从1970年开始,以实验细胞学的方法,研究肿瘤免疫问题。1972年曾初步报告研究成果,实验以大白鼠Walker癌肉瘤为对象,用两种方法进行研究。(一)以肿瘤细胞与正常细胞(鸡红血球或小鼠脾脏细胞)融合的肿瘤更多还原

【Abstract】 The present study is a follow-up of our previous work which was given at the meeting of the Cancer Society of Peking in 1972.Hybrid cells formed by UV-inactivated Sendai virus-induced fusion of Walker-256 carcinoma cells and cock erythrocytes were used to immunize against Wistar rat’s Walker carcinoma.Using fluorescent microscopy,the surface antigens of both parents were found over the entire hybrid cells.Of 68 immunized rats,10 (14.7%) produced tumours and died between 18-60 days (average 30.5 days).Thus,fifty-eight (85.3%) survived.Some of them bore no tumours,while others produced tumours but finally regressed.All 68 control rats developed tumours.Fifty-five (80.9%) of them died between 12-50 days (average 23.7 days) and 13 (19.1%) survived.It was discussed that the function of tumour hybrid cells is possibly to stimulate the host immune system and that the tumour hybrids may be used as an immuno-therapeutic agent to destroy the residual tumour cells after surgery or other treatments.更多还原