【摘要】 目的 探究影响抗富亮氨酸胶质瘤失活蛋白1(LGI1)抗体脑炎复发的因素。方法 回顾性收集郑州大学第一附属医院2017年5月至2021年10月确诊为抗LGI1抗体脑炎的40例患者的临床资料，出院后随访至少7个月，根据患者随访期间是否复发将选入病例分为复发组和未复发组，其中复发组12例，未复发组28例。收集所有患者的一般资料、临床特征、检查检验结果，对两组之间各项指标进行单因素分析，根据统计结果进行多因素logistic回归分析筛选抗LGI1抗体脑炎复发的影响因素。结果 单因素分析结果示，复发组脑脊液淋巴细胞、血清免疫球蛋白、外周血淋巴细胞和嗜碱性粒细胞低于未复发组，且差异具有统计学意义(P<0.05),复发组脑脊液单核细胞、外周血中性粒细胞高于未复发组，差异具有统计学意义(P<0.05)。两组患者的性别、年龄、起病方式、是否重症以及基础疾病之间的差异无统计学意义(P>0.05)。多因素logistic回归分析示脑脊液单核细胞、外周血淋巴细胞(OR=1.231,0.800,P<0.05)是抗LGI1抗体脑炎复发的独立危险因素。结论 脑脊液单核细胞偏高及外周血淋巴细胞偏低是抗LGI1抗体脑炎复发的独立危险因素。更多还原

【Abstract】 Objective To explore the factors influencing the recurrence of anti-leucine-rich glioma-inactivated 1(LGI1) antibody encephalitis.Methods The clinical data of 40 patients with anti-LGI1 antibody encephalitis in the First Affiliated Hospital of Zhengzhou University from May 2017 to October 2021 were collected. The patients were followed up for least 7 months after discharge. The patients were divided into a recurrence group(12 patients) and a non-recurrence group(28 patients) according to whether they relapsed after discharge. The demographic information, clinical characteristics and experimental results of all patients were collected. Univariate analysis was performed for each index between the two groups, and multivariate logistic regression analysis was performed to screen the influencing factors of recurrence of anti-LGI1 antibody encephalitis according to the statistical results.Results The results of univariate analysis showed that cerebrospinal fluid lymphocytes, serum immunoglobulin, peripheral blood lymphocytes and basophils in the recurrence group were lower than those in the non-recurrence group, and the difference was statistically significant(P<0.05). The cerebrospinal fluid monocytes and peripheral blood neutrophils in the recurrence group were higher than those in the non-recurrence group, and the difference was statistically significant(P<0.05). There are no significant differences in gender, age, onset mode, severity, or underlying diseases between the two groups(P>0.05). Multivariate logistic regression analysis showed that cerebrospinal fluid monocytes and peripheral blood lymphocytes(OR=1.231, 0.800, P<0.05) were independent risk factors for recurrence.Conclusion The high level of monocytes in cerebrospinal fluid and low level of lymphocytes in peripheral blood are independent risk factors for recurrence of anti-LGI1 antibody encephalitis.更多还原